Endocrine Abstracts

Identification of pure neural androgenic effects is difficult due to 1) regional distribution of androgen receptors (AR) in the CNS; 2) cross-talk between molecular pathways of steroid hormone signalling, and 3) chemical nature and biotransformation of androgens in the CNS. Testosterone is transformed in the CNS by 5α-reductase and aromatase to the pure AR-agonist dihydrotestosterone (DHT) and the estrogen receptor-agonist estradiol, respectively. Decreased sexual activit...